Cross-linking can be good

combined oxidase/peroxidase that does the cross-linking, the cuticle separates into distinct layers, resulting in translucent worms that often suffer from massive blisters and defective movement. The clue that the cross-linking enzyme (called Duox for Dual Oxidase) might exist came from studies of phagocyte NADPH-oxidase. The latter enzyme generates bursts of superoxide to effect killing of engulfed cells. But other cell types, some of which lack phagocyte NADPHoxidase, generate lower levels of reactive oxygen species. Duox may be one of the sources of Worms without Duox (left) are translucent and often burst.